FK-330 dihydrate (FR-260330 dihydrate) is a novel and effective nitric oxide synthase inhibitor. It can prevent ischemia and reperfusion injury in rat liver transplantation.

AR-C102222 is a potent, selective iNOS inhibitor with IC50 of 35 nM, dislapys 3,000-fold and 20-fold selectivity over eNOS and nNOS respectively; reduces inflammation produced by the application of arachidonic acid to the ear, attenuates FCA-induced mechanical hyperalgesia, and attenuates acetic acid-induced writhing in mice.Rheumatoid ArthritisDiscontinued

2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS;?Ki of 21.8 and 37.5 μM for mouse iNOS and rat nNOS respectively).