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EGFR-IN-87

CAS No. 1835666-87-9

EGFR-IN-87( —— )

Catalog No. M37255 CAS No. 1835666-87-9

EGFR-IN-87 is a potent EGFR tyrosine kinase inhibitor with anticancer activity that inhibits EGFR_d746-750, EGFR_L858R/T790M, and EGFR_WT in A431 cells, and can be used for cancer research.

Purity : >98% (HPLC)

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Biological Information

Product Name

EGFR-IN-87
Note

Research use only, not for human use.
Brief Description

EGFR-IN-87 is a potent EGFR tyrosine kinase inhibitor with anticancer activity that inhibits EGFR_d746-750, EGFR_L858R/T790M, and EGFR_WT in A431 cells, and can be used for cancer research.
Description

EGFR-IN-87 is a EGFR tyrosine kinase inhibitor. EGFR-IN-87 has IC50 value of 3.1 nM, 1.3 nM and 7.1 nM for EGFR_d746-750, EGFR_L858R/T790 and EGFR_WT in A431 cells, respectively. EGFR-IN-87 can be used for cancer diseases research.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Proteasome/Ubiquitin
Target

Tyrosinase
Recptor

Tyrosine Kinases
Research Area

——
Indication

——

Chemical Information

CAS Number

1835666-87-9
Formula Weight

499.61
Molecular Formula

C28H33N7O2
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C=C)NC1=CC(NC2=NC=CC(=N2)N3C=C(C=4C=CC=CC43)C)=C(OC)C=C1N(C)CCN(C)C
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Song Y.T, et al. Selective inhibitors of clinically important mutants of the egfr tyrosine kinase. The United States, WO2017120429 A1. 2017-07-13.

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