Difamilast( OPA-15406 | OPA15406 )

Catalog No. M16718 CAS No. 937782-05-3

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Product Name

Difamilast
Note

Research use only, not for human use.
Brief Description

Difamilast (OPA-15406) is a novel potent, selective phosphodiesterase IV (PDE4) inhibitor with preference for PDE4B (IC50=11.2 nM).?
Description

Difamilast (OPA-15406) is a novel potent, selective phosphodiesterase IV (PDE4) inhibitor with preference for PDE4B (IC50=11.2 nM).?Dermatitis Phase 2 Clinical.
In Vitro

OPA-15406 is highly selective for inhibition of PDE4 subtype B (IC50=11.2 nM), and OPA-15406 also exerts inhibitory effects on PDE2.
In Vivo

OPA-1540 improves skin condition in relevant animal models of AD.
Synonyms

OPA-15406 | OPA15406
Pathway

Angiogenesis
Target

PDE
Recptor

PDE
Research Area

Inflammation/Immunology
Indication

Dermatitis

CAS Number

937782-05-3
Formula Weight

446.451
Molecular Formula

3H24F2N2O5
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (223.99 mM)
SMILES

O=C(NCC1=COC(C2=CC=C(OC(F)F)C(OC(C)C)=C2)=N1)C3=CC=CC=C3OCC
Chemical Name

N-({2-[4-(difluoromethoxy)-3-(propan-2-yloxy)phenyl]-1,3-oxazol-4-yl}methyl)-2-ethoxybenzamide

1.?Hanifin JM, et al. J Am Acad Dermatol. 2016 Aug;75(2):297-305.

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