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Cipemastat
CAS No. 174265-38-4
Cipemastat( Ro 32-3555 )
Catalog No. M12643 CAS No. 174265-38-4
Cipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCipemastat
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NoteResearch use only, not for human use.
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Brief DescriptionCipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor.
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DescriptionCipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor, preferentially inhibits collagenases (MMP-1, -8, and -13) and gelatinase B (MMP-9); inhibits human collagenases 1, 2 and 3 (Ki of 3.0, 4.4 and 3.4 nM), and Ro 323555 is a selective inhibitor of collagenases over the related stromelysin 1, and gelatinases A and B (Ki of 527, 154 and 59 nM); prevents cartilage breakdown both in vitro and in vivo.Rheumatoid Arthritis Phase 3 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsRo 32-3555
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PathwayMetabolic Enzyme/Protease
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TargetMMP
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RecptorMMP
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Research AreaInflammation/Immunology
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IndicationRheumatoid Arthritis
Chemical Information
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CAS Number174265-38-4
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Formula Weight436.553
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Molecular FormulaC22H36N4O5
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name1-Piperidinebutanamide, b-(cyclopentylmethyl)-N-hydroxy-g-oxo-a-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lewis EJ, et al. Br J Pharmacol. 1997 Jun;121(3):540-6.
2. Whittaker M, et al. Chem Rev. 1999 Sep 8;99(9):2735-76.
3. Liechti FD, et al. Infect Immun. 2014 Apr;82(4):1710-8.
4. Brewster M, et al. Arthritis Rheum. 1998 Sep;41(9):1639-44.
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