Cinchonine

Research use only, not for human use.

A local anesthetic of the amide type now generally used for surface anesthesia.

A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia.

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Animal Model:BALB/c nude mice Dosage:4 mg/kg/day Administration:Intraperitoneal injection, for 19 days Result:Inhibited metastatic activity Animal Model:BALB/c nude mice Dosage:0.265 and 0.530 mg/kg Administration:Intratumorally injection, for 14 days Result:Inhibited tumor growth with more TUNEL positive cells (DNA fragmentation indicator).Animal Model:High-fat-diet (HFD) induced obesity in C57BL/6B mice Dosage:50 mg/kg Administration:Intraperitoneal injection Result:Reduced body weight gain (?38%), visceral fat-pad weights (?26%).

Cinchonine | NSC 6176 | NSC-6176 | NSC6176

Endocrinology/Hormones

CaMK

CAM| Sodium Channel

Inflammation/Immunology

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118-10-5

294.39

C19H22N2O

>98% (HPLC)

Water: 42 mg/L (at 21 °C)

OC(C1N2CC(C=C)C(CC2)C1)C3=CC=NC4=CC=CC=C34

alpha-(5-Vinyl-2-quinuclidinyl)-4-quinolinemethanol

(-20℃)

With Ice Pack

≥ 2 years