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CHF6001

CAS No. 1239278-59-1

CHF6001( CHF-6001 | CHF 6001 )

Catalog No. M10961 CAS No. 1239278-59-1

A novel, highly potent and selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 0.026 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CHF6001
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel, highly potent and selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 0.026 nM.
  • Description
    A novel, highly potent and selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 0.026 nM; inhibits PDE4 isoforms A-D with equal potency, 7- and 923-fold more potent than roflumilast and cilomilast, and displays >20,000-fold selectivity versus PDE4 compared with a panel of PDEs; effectively inhibits (subnanomolar IC50 values) the release of TNF-α from human PBMCs, THP-1, and rodent macrophages; inhibitsLPS-induced pulmonary neutrophilia (ED50=0.205 uM/kg) and leukocyte infiltration (ED50=0.188 uM/kg) in rats.COPD Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CHF-6001 | CHF 6001
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE
  • Research Area
    Inflammation/Immunology
  • Indication
    COPD

Chemical Information

  • CAS Number
    1239278-59-1
  • Formula Weight
    687.533
  • Molecular Formula
    C30H30Cl2F2N2O8S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(O[C@H](C1=CC=C(OC(F)F)C(OCC2CC2)=C1)CC3=C(Cl)C=[N+]([O-])C=C3Cl)C4=CC=C(NS(=O)(C)=O)C(OCC5CC5)=C4
  • Chemical Name
    (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)ethyl)pyridine 1-oxide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Armani E, et al. J Med Chem. 2014 Feb 13;57(3):793-816. 2. Villetti G, et al .J Pharmacol Exp Ther. 2015 Mar;352(3):568-78. 3. Moretto N, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):559-67. 4. Edwards MR, et al. Pharmacol Res Perspect. 2016 Jan 15;4(1):e00202.
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