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Beloranib
CAS No. 251111-30-5
Beloranib( CKD-732 | ZGN-433 | ZGN-440 )
Catalog No. M13740 CAS No. 251111-30-5
An analog of the natural compound Fumagillin that functions as a highly potent methionine aminopeptidase 2 (MetAP2) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 2583 | Get Quote |
|
| 50MG | 5202 | Get Quote |
|
| 100MG | 7380 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBeloranib
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NoteResearch use only, not for human use.
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Brief DescriptionAn analog of the natural compound Fumagillin that functions as a highly potent methionine aminopeptidase 2 (MetAP2) inhibitor.
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DescriptionAn analog of the natural compound Fumagillin that functions as a highly potent methionine aminopeptidase 2 (MetAP2) inhibitor; strongly inhibit the growth of cancers in xenografted nude model; also causes significant body weight and appetite reduction an anti-obesity agent.Obesity Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsCKD-732 | ZGN-433 | ZGN-440
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PathwayMetabolic Enzyme/Protease
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TargetAminopeptidase
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RecptorAminopeptidase
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Research AreaMetabolic Disease
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IndicationObesity
Chemical Information
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CAS Number251111-30-5
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Formula Weight499.65
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Molecular FormulaC29H41NO6
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O[C@H](CC1)[C@@H](OC)[C@H]([C@@]2(C)O[C@@H]2C/C=C(C)\C)[C@]31CO3)/C=C/C4=CC=C(OCCN(C)C)C=C4
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Chemical Name[(3R,6R,7S,8S)-7-methoxy-8-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-2-oxaspiro[2.5]octan-6-yl] (E)-3-[4-[2-(dimethylamino)ethoxy]phenyl]prop-2-enoate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kim YM, et al. J Mol Endocrinol. 2007 Apr;38(4):455-65.
2. Morgen M, et al. ACS Chem Biol. 2016 Apr 15;11(4):1001-11.
3. Chun E, et al. Int J Cancer. 2005 Mar 10;114(1):124-30.
4. Hughes TE, et al. Obesity (Silver Spring). 2013 Sep;21(9):1782-8.
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