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BRD-7880
CAS No. 1456542-69-0
BRD-7880( BRD 7880 | BRD7880 )
Catalog No. M11969 CAS No. 1456542-69-0
A potent and highly specific inhibitor of Aurora B and Aurora C with IC50 of 7 and 12 nM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1683 | Get Quote |
|
| 50MG | 3402 | Get Quote |
|
| 100MG | 4680 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBRD-7880
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and highly specific inhibitor of Aurora B and Aurora C with IC50 of 7 and 12 nM respectively.
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DescriptionA potent and highly specific inhibitor of Aurora B and Aurora C with IC50 of 7 and 12 nM respectively, with less activity against Aurora A (IC50>2 uM); is far more selective than tozasertib (VX-680), substantially inhibiting (to < 25% control activity) only AURKB and AURKC in a panel of 308 kinases.
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In Vitro——
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In Vivo——
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SynonymsBRD 7880 | BRD7880
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PathwayCell Cycle/DNA Damage
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TargetAurora Kinase
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RecptorAurora Kinase
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Research Area——
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Indication——
Chemical Information
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CAS Number1456542-69-0
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Formula Weight590.677
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Molecular FormulaC32H38N4O7
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC1=CC=C(OC)C=C1)NC2=CC=C(O[C@@H](CN(CC3=CC=C(OCO4)C4=C3)C)[C@@H](C)CN([C@@H](C)CO)C5=O)C5=C2
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Chemical Name1-((2R,3S)-2-(((benzo[d][1,3]dioxol-5-ylmethyl)(methyl)amino)methyl)-5-((S)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-8-yl)-3-(4-methoxyphenyl)urea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yu C, et al. Nat Biotechnol. 2016 Apr;34(4):419-23.
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