Ac-YVAD-CHO( —— )

Catalog No. M33640 CAS No. 143313-51-3

Ac-YVAD-CHO (L 709049) is a selective and potent tetrapeptide interleukin 1β-converting enzyme (ICE) and caspase-1 (ICE)-like protease inhibitor with anti-inflammatory activity.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Ac-YVAD-CHO
Note

Research use only, not for human use.
Brief Description

Ac-YVAD-CHO (L 709049) is a selective and potent tetrapeptide interleukin 1β-converting enzyme (ICE) and caspase-1 (ICE)-like protease inhibitor with anti-inflammatory activity.
Description

Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a caspase-1 inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ.
In Vitro

Western Blot Analysis Cell Line:SNAP-treated thymocytes Concentration:15.6 μM Incubation Time:12 h Result:Reduced PARP cleavage.
In Vivo

Animal Model:P. acnes-sensitized miceDosage:50 mg/kg Administration:I.p.; Result: Suppressed IL-1β levels in blood.Animal Model:Quinolinic acid-treated RatsDosage:2-8 μg Administration:Intrastriatal infusion. Result:Attenuated Quinolinic acid (QA)-induced increases in p53 and apoptosis in rat striatum.Inhibited QA-induced increases in caspase-1 activity and p53 protein levels, with no effect on QA-induced IκB-α degradation, NF-κB or AP-1 activation.
Synonyms

——
Pathway

Apoptosis
Target

Caspase
Recptor

Caspase | Apoptosis
Research Area

——
Indication

——

Chemical Information

CAS Number

143313-51-3
Formula Weight

492.52
Molecular Formula

C23H32N4O8
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : ≥ 50 mg/mL (101.52 mM)* "≥" means soluble, but saturation unknown.
SMILES

[C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC(C)=O)=O)(C(N[C@H](C(N[C@@H](CC(O)=O)C=O)=O)C)=O)C(C)C
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Fletcher DS, et al. A synthetic inhibitor of interleukin-1 beta converting enzyme prevents endotoxin-induced interleukin-1 beta production in vitro and in vivo. J Interferon Cytokine Res. 1995;15(3):243-248.?

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