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Home - Products - Cell Cycle/DNA Damage - Aurora Kinase - AZD1152-HQPA

AZD1152-HQPA

CAS No. 722544-51-6

AZD1152-HQPA( Barasertib | AZD2811 )

Catalog No. M15765 CAS No. 722544-51-6

The active product of AZD1152, a potent, selective inhibitor of Aurora B kinase with IC50 of 0.37 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AZD1152-HQPA
  • Note
    Research use only, not for human use.
  • Brief Description
    The active product of AZD1152, a potent, selective inhibitor of Aurora B kinase with IC50 of 0.37 nM.
  • Description
    The active product of AZD1152, a potent, selective inhibitor of Aurora B kinase with IC50 of 0.37 nM; displays >3,700-fol selectivity for Aurora B over Aurora A; potently inhibits the growth of human colon, lung, and hematologic tumor xenografts.
  • In Vitro
    Cell Proliferation Assay.Cell Line:AML lines (HL-60, NB4, MOLM13), ALL line (PALL-2), biphenotypic leukemia (MV4-11), acute eosinophilic leukemia (EOL-1), and the blast crisis of chronic myeloid leukemia K562 cells.Concentration:0-100 nM. (Barasertib -HQPA)Incubation Time:48 h.Result:IC50 values ranged from 3 nM to 40 nM.
  • In Vivo
    ——
  • Synonyms
    Barasertib | AZD2811
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Aurora Kinase
  • Recptor
    AuroraA|AuroraB
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    722544-51-6
  • Formula Weight
    507.5599
  • Molecular Formula
    C26H30FN7O3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(NC1=CC=CC(F)=C1)CC2=CC(NC3=C4C=CC(OCCCN(CC)CCO)=CC4=NC=N3)=NN2
  • Chemical Name
    1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Grundy M, et al. Mol Cancer Ther. 2010 Mar;9(3):661-72. 2. Mortlock AA, et al. J Med Chem. 2007 May 3;50(9):2213-24. Epub 2007 Mar 21. 3. Wilkinson RW, et al. Clin Cancer Res. 2007 Jun 15;13(12):3682-8.
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