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Home - Products - Membrane Transporter/Ion Channel - Proton Pump - AZD-0865

AZD-0865

CAS No. 248919-64-4

AZD-0865( Linaprazan | AZD0865 | AZD 0865 )

Catalog No. M13729 CAS No. 248919-64-4

A potent, selective acid pump antagonist (potassium-competitive acid blocker or P-CAB) that reversiblely inhibits gastric H+/K+-ATPase with pIC50 of 6.5.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AZD-0865
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective acid pump antagonist (potassium-competitive acid blocker or P-CAB) that reversiblely inhibits gastric H+/K+-ATPase with pIC50 of 6.5.
  • Description
    A potent, selective acid pump antagonist (potassium-competitive acid blocker or P-CAB) that reversiblely inhibits gastric H+/K+-ATPase with pIC50 of 6.5; inhibits H+/K+-ATPase activity in a K(+)-competitive manner with Ki of 46 nM, shows no ativity for porcine renal Na(+),K(+)-ATPase at 100 uM; inhibits gastric acid secretion in vivo.UlcerPhase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Linaprazan | AZD0865 | AZD 0865
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Proton Pump
  • Recptor
    Proton Pump
  • Research Area
    Other Indications
  • Indication
    Ulcer

Chemical Information

  • CAS Number
    248919-64-4
  • Formula Weight
    366.4567
  • Molecular Formula
    C21H26N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 35 mg/mL
  • SMILES
    CC1=C(C(=CC=C1)C)CNC2=CC(=CN3C2=NC(=C3C)C)C(=O)NCCO
  • Chemical Name
    Imidazo[1,2-a]pyridine-6-carboxamide, 8-[[(2,6-dimethylphenyl)methyl]amino]-N-(2-hydroxyethyl)-2,3-dimethyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bailey N, et al. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3602-6. 2. Gedda K, et al. Biochem Pharmacol. 2007 Jan 15;73(2):198-205. 3. Kirchhoff P, et al. Am J Physiol Gastrointest Liver Physiol. 2006 Nov;291(5):G838-43.
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